By Shaker A. Mousa (auth.), Shaker A. Mousa (eds.)

ISBN-10: 1607618028

ISBN-13: 9781607618027

ISBN-10: 1607618036

ISBN-13: 9781607618034

During the prior decade, outstanding growth has been made within the improvement of more moderen medications to avoid and deal with thromboembolic problems, reminiscent of oral direct anti-Xa and anti-IIa antagonists, in addition to oral antiplatelet ADP antagonists with speedy onset and offset. furthermore, there was centred attempt geared toward determining novel makes use of of conventional antithrombotic medicinal drugs, equivalent to aspirin, heparin, and oral anticoagulants, in addition to combos of brokers, resembling multiple antiplatelet, antiplatelet with anticoagulant, antiplatelet without or with thrombolytic. Anticoagulants, Antiplatelets, and Thrombolytics, moment variation presents updates on a variety of suggestions in thrombosis, experimental types, and medical and up to date advances within the discovery and improvement of novel antithrombotics. As a quantity within the hugely winning tools in Molecular Biology™ sequence, this assortment offers the type of distinctive description and implementation suggestion that's an important for buying optimum effects. effortless to take advantage of and recent, Anticoagulants, Antiplatelets, and Thrombolytics, moment variation is a perfect consultant for researchers aiming for the way forward for this important box, concentrating on the prevention of thromboembolic problems and the security of the vascular endothelium.

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Additional resources for Anticoagulants, Antiplatelets, and Thrombolytics: Second Edition

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The rabbit ear blood loss model is most commonly used to test the hemorrhagic effect of drugs. The rat tail bleeding models have also been utilized for the study of several antithrombotic drugs. These animal models have been well established and can be used for the development of antithrombotic drugs. It is also pos- In Vivo Models for the Evaluation of Antithrombotics and Thrombolytics 31 sible to use the standardized bleeding and thrombosis models to predict the safety and efficacy of drugs. Thus, in addition to the evaluation of in vitro potency, the endogenous effects of antithrombotic drugs can be investigated.

Such data can only be obtained using animal models. It is therefore important to design experiments where several data points can be obtained. This information is of crucial value in the assessment of antithrombotic drugs and cannot be substituted by other in vitro or tissue culture-based methods. Several excellent reviews covering the different theoretical and technical aspects of thrombosis and thrombolysis models have been published previously (2, 11–15). These reviews, along with more specialized reviews of models of atherosclerosis (16), restenosis (17), and stroke (18) provide comprehensive information regarding the details of many models and provide the pathological rationale for using specific models for specific diseases.

18 Mousa between the two stainless steel plates of the viscometer. Rotation of the upper conical plate causes a well-defined and uniform shear stress to be applied to the entire fluid medium (1). The shear rate (γ ) in this system can be readily calculated from the cone angle and the speed of the cone using the following formula: γ = 2πω 60θcp , where γ is the shear rate per second, ω is the cone rotational rate in revolutions per minute (rev/min) and θ cp is the cone angle in radians. 0◦ . 04 cp at 37◦ C).

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Anticoagulants, Antiplatelets, and Thrombolytics: Second Edition by Shaker A. Mousa (auth.), Shaker A. Mousa (eds.)


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